Aligned electrospun PLGA fibres reinforcing tubular small intestine submucosa

摘要

It was concluded that the addition of an electrospun fibre layer resulted in an increase in the elastic modulus, yield strength and the failure strain of SIS when compared to the control. It was also shown that with rotation of the mandrel at speeds of 2000rpm or higher that the fibres became more highly aligned. The alignment of the fibres resulted in changes in the mechanical properties and it was concluded that the SIS with the player of fibres spun at 2000rpm had the best balance of elastic modulus, yield stress and failure strain when tested longitudinally and circumferentially. It was speculated that the lower degree of entanglement when the fibres were highly aligned resulted in less mechanical reinforcement when the scaffold was stressed perpendicularly to the alignment of the fibres.