Extracellular matrix proteins regulate Adipose Derived Mesenchymal Stem Cells and Amniotk Fluid Stem Cells attachment and proliferation: utility for tissue and organ regeneration

摘要

These results suggest that the signal transduction of the cell-matrix interaction for the proliferation and adhesion of hADSCs and hAFSCs was activated when cultured on collagen Ⅳ and fibronectin-coated dishes. Its indicates on ECM as an important component of the cellular niche in the tissue, supplying critical biochemical and physical signals to initiate or sustain cellular functions. It is also possible that ECM is required for the reconstitution of the niche of stem cells in vitro.