Influence Factors for the Optical Parameters Measurement with Time-resolved Diffusion Reflectance

摘要

The diffuse light detected from tissue surface contains the information about the tissue optical parameters. How to extract tissue optical parameters from the reflectance light with accuracy plays a significant role in optical diagnosis. A nonlinear least square fitting algorithm was used to display the fitting accuracy influenced by the fitting start time, the fitting end time, the two parameters fitting (μ_a、μ_s) and the three parameters fitting (μ_a、 μ_s、 amplitude factor A) on the basis of the MC simulation. A comparison is made between the results that to use the diffuse reflectance data with a certain detecting angle to fit to the diffuse reflectance formula based on the full angle detecting and to fit to the diffusion formula based on corresponding detecting angle respectively. The influences of different nonlinear least square fitting algorithm on the fitting accuracy and on the fitting time are also discussed. The result shows that the optical parameters determination is influenced by many factors. It may play a significant role in improving the fitting accuracy of tissue optical parameters and in the tissue noninvasive diagnosis.