THE ASSOCIATION BETWEEN INTRAUTERINE EXPOSURE TO PERSISTENT ORGANOCHLORINE POLLUTANTS AND TYPE 1 DIABETES:A CASE-CONTROL STUDY

摘要

It is of great importance to investigate suggested triggering factors for the risk of developing type 1 diabetes. The present study aimed to investigate the hypothesized association between persistent organochlorine pollutants (POP) and type 1 diabetes. It was performed as a case-control study within a biobank in Malm(o), which is located in the Southern part of Sweden. The study included 150 cases (children who had developed type 1 diabetes) and 150 controls. As biomarkers for POP exposure we used 2,2',4,4',5,5'-heaxchlorobiphenyl (CB-153) and the major DDT metabolite 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE). The hypothesis that in utero exposure to POPs will trigger the risk for developing type 1 diabetes was not supported by the results from the current study. When comparing the quartile with the highest maternal serum concentrations of CB-153 with the other quartiles, an odds ratio (OR) of 0.73 (95% confidence interval [CI] 0.42, 1.27) was obtained. Similar results was obtained for p,p'-DDE (OR 0.56, 95% CI 0.29, 1.08).