CONTAINERS FOR DRUG DELIVERY BASED ON VATERITE PARTICLES

摘要

Calcium carbonate is an important inorganic biomaterial thanks to its chemical stability, bioactivity, and biocompatibility. These properties have recently made it an interesting candidate for drug delivery systems. Calcium carbonate exists in three anhydrous polymorphic modifications: vaterite, aragonite, and calcite. Under normal conditions, vaterite is an unstable phase, while calcite and aragonite are stable. The transition between these phases can be exploited as a payload release mechanism. Vaterite polycrystalline particles have further favorable properties like high porosity, large surface area, and negative zeta potential.