Evaluation of Poly(alkylcyanoacrylate) Nanoparticles as Delivery Systems for Vaccine Antigens

摘要

Two poly(ethylcyanoacrylate) nanoparticlepreparations prepared using either 100 or 600 mgmonomer encapsulating ovalbumin wereevaluated in terms of their ability to stimulate animmune response in mice. Following a primingand a booster dose (week 6) serum IgG wereobserved to be in the order Freunds >nanocapsules (600mg) > nanocapsules (100mg)> solution. No significant difference wasobserved between the two nanocapsulepreparations but a large variability between micewas noted for these systems.