Amphiphilic Diblock Copolymer-Based Drug Nanoparticle Formation Using Confined ImpingingJets Mixers

摘要

We present a new process to encapsulatehydrophobic drugs based on diblock copolymerarrestednucleation and growth of drugnanoparticles. This process allowed us toencapsulate ?-carotene in poly(styrene)-b-poly(ethylene oxide), and paclitaxel in poly(ecaprolactone)-b-poly(ethylene glycol) and poly(ecaprolactone)homopolymer nanoparticles, withcontrolled sizes between 80 and 450 nm, and highdrug loading.