Long-term Erosion of Swollen Hydrogels Crosslinked by Hydrolyzable Polyrotaxanes

摘要

Poly(ethylene glycol) (PEG) hydrogels crosslinkedby a hydrolyzable polyrotaxane with high molecularweight completely eroded around one year even inswollen states. The mechanism of the long-termerosion of the swollen hydrogels was ascribed toinclusion complexation of ester linkages in thepolyrotaxane. The long-term erosion and completedegradation are promising features for tissuescaffolds and implantable drug delivery.