Preparation and In-vitro Characterization of ProniosomesBearing Diclofenac Sodium

摘要

Dry granular free flowing powder of nonionicsurfactants (proniosomes) has beenprepared. Such proniosomes are an alternativeapproach to liposomes, which are highlyunstable due to oxidation, hydrolysis,aggregation, fusion.These proniosomes wereprepared containing Diclofenac sodium bytaking optimized ratio of Brij 30/cholesterol anddicetyl phosphate using slurry method.Proniosome derived niosome dispersions wasobtained by hydrating proniosome preparationwith 70°C distilled water and vortex mixing for 2minute. The resulting niosome dispersion wascharacterized for entrapment efficiency, angleof repose, and release profile. The entrapmentefficiency of Diclofenac sodium was found to be80.5 ± 1.5%. The angle of repose ofproniosome (35.75±1.7) was less than plainmaltodextrin (44.28±1.2), which is due tosmoother surface provided by surfactants. Therelease of drug was much faster in gastric fluid(about 79% in 8 hrs) compared to intestinal fluid(15.8% in 8 hrs). These dry products ofproniosome appear to be promising andindustrially suitable. Since they are highly stableand requires no special conditions of storageand unit dose can be fixed based onentrapment efficiency and spontaneity.