Effect of Tocopheryl Polyethylene Glycol Succinate (TPGS) on Percutaneous Penetration of Minoxidilfrom Water/Ethanol/Polyethylene glycol (PEG) Solutions

摘要

Solubility of minoxidil was improved withincreasing TPGS concentrations only in solvent systemthat containing 100% water. TPGS has a significant effecton percutaneous penetration of minoxidil from thosesolvent compositions with a higher solubility parameterwith increasing concentration of TPGS (15～20%) addedin the formulations resulting in the hindrance of the fluxand the reduced retention amount of minoxidil in the skin.