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PREPARATION OF NANOSTRUCTURED PARTICLES OF POORLY WATER SOLUBLE DRUGS VIAA NOVEL ULTRA-RAPID FREEZING (URF) TECHNOLOGY

机译：新型超快速冷冻（URF）技术制备难溶性药物的纳米结构颗粒

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Nanostructured particles of API(s) stabilized withexcipient(s) have been prepared via a novel particleengineering technology - ultra-rapid freezing (URF) andisolated by either lyophilization or atmospheric fluidizedbed drying. The ultra-rapid freezing processed materialsachieved significantly higher dissolution rates than themicronized API or physical mix.

机译：纳米结构化的API稳定颗粒赋形剂是通过新型颗粒制备的工程技术-超快速冷冻（URF）和通过冻干或大气流化分离床干燥。超快速冷冻加工材料达到的溶出率明显高于微粉化的API或物理混合物。

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《Controlled Release Society 31st annual meeting transactions: abstracts 》|2004年|1-2|共2页
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Jonathan C. Evans; Brian D. Scherzer; Carlene D. Kozuch; Gary B. Kupperblatt; Shakil Saghir; Edmund J. Elder;
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Nanostructured particles; cryogenic; dissolution; thermal analysis; capsules; tablets; bioavailability;

机译：纳米结构颗粒;低温解散热分析;胶囊平板电脑生物利用度;

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1. 通过简单微波法使用新型硫化剂制备HgS纳米颗粒的结构与光谱表征 [J] . Hossein SAFARDOUST-HOJAGHAN, Maryam SHAKOURI-ARANI, Masoud SALAVATI-NIASARI 中国有色金属学报（英文版） . 2016 ,第003期
2. 通过简单微波法使用新型硫化剂制备HgS纳米颗粒的结构与光谱表征（英文） [J] . Hossein SAFARDOUST-HOJAGHAN, Maryam SHAKOURI-ARANI, Masoud SALAVATI-NIASARI 中国有色金属学报：英文版 . 2016 ,第003期
3. Novel ultra-rapid freezing particle engineering process for enhancement of dissolution rates of poorly water-soluble drugs. [J] . Overhoff KA, Engstrom JD, Chen B, European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2007 ,第1期

机译：新颖的超快速冷冻颗粒工程工艺，可提高水溶性差的药物的溶出度。
4. Spray freezing into liquid (SFL) particle engineering technology to enhance dissolution of poorly water soluble drugs: organic solvent versus organic/aqueous co-solvent systems. [J] . Hu J, Johnston KP, Williams RO 3rd European journal of pharmaceutical sciences . 2003 ,第3期

机译：将冷冻剂喷雾到液体（SFL）颗粒工程技术中，以增强水溶性差的药物的溶解：有机溶剂与有机/水性助溶剂系统的比较。
5. Enhanced aqueous dissolution of a poorly water soluble drug by novel particle engineering technology: spray-freezing into liquid with atmospheric freeze-drying. [J] . Rogers TL, Nelsen AC, Sarkari M, Pharmaceutical research . 2003 ,第3期

机译：通过新的粒子工程技术增强了水溶性差的药物的水溶解性：通过大气冷冻干燥将其喷雾冷冻成液体。
6. PREPARATION OF NANOSTRUCTURED PARTICLES OF POORLY WATER SOLUBLE DRUGS VIA A NOVEL ULTRA-RAPID FREEZING (URF) TECHNOLOGY [C] . Controlled Release Society annual meeting . 2004

机译：通过新型超快速冻结（URF）技术制备少量水溶性药物颗粒
7. A nanoparticle engineering process: Spray-freezing into liquid to enhance the dissolution of poorly water soluble drugs. [D] . Hu, Jiahui. 2003

机译：纳米粒子工程过程：将喷雾喷雾冷冻到液体中以增强水溶性差的药物的溶解。
8. Novel Biodegradable Polyester Poly(Propylene Succinate): Synthesis and Application in the Preparation of Solid Dispersions and Nanoparticles of a Water-Soluble Drug [O] . Dimitrios N. Bikiaris, George Z. Papageorgiou, Sofia A. Papadimitriou, 2009

机译：新型可生物降解的聚酯聚琥珀酸丙二醇酯：在水溶性药物的固体分散体和纳米颗粒的制备中的合成与应用
9. Unimolecular branched block copolymer nanoparticles in methanol for the preparation of poorly water-soluble drug nanoparticles [O] . Liu J-H, Wais U, Zuo Y-M, 2017

机译：甲醇中的单分子支链嵌段共聚物纳米粒子，用于制备水溶性差的药物纳米粒子

PREPARATION OF NANOSTRUCTURED PARTICLES OF POORLY WATER SOLUBLE DRUGS VIAA NOVEL ULTRA-RAPID FREEZING (URF) TECHNOLOGY

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