In order to solve the problem of blindly estimation of pseudo random (PN) sequence of DS-CDMA signal in multipath channel, On the basis of asynchronous DS-CDMA signal model, this paper proposed a new algorithm combined Independent component analysis(ICA) and data reuse blind equalization. In multipath channel, the estimation of ICA is the overlapped form of PN sequences of different paths, then data reuse blind equalization is introduced to eliminate the influence of the multipath, and the PN sequences of each user can be estimated from the result of blind equalization. This algorithm is no limit to the type of PN sequence, which is effective to m sequence, Gold sequence, M sequence and so on. The computer simulation shows that the algorithm performs well when the Signal to Noise Ratio(SNR) is even below 0dB.
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