A Promising Cancer Treatment Modality: The University of California Davis/McClellan Nuclear Radiation Center Neutron Capture Therapy Program

摘要

Neutron capture therapy (NCT) is a promising new binary therapeutic modality for the treatment of localized tumors. It is accomplished by injection and localization within the tumor of a neutron capture agent (NCA) that alone, is non-toxic. When the tumor is then exposed to neutrons, a relatively non-toxic form of radiation, cytotoxic products are produced that directly or indirectly cause tumor cell death, and yet preserves normal surrounding tissue not containing the NCA. The UC Davis NCT program is currently working to develop and test new compounds or neutron capture agents (NCA) in vitro and in vivo. Many groups worldwide are also working to develop the next generation NCA, but less than five facilities internationally are currently capable of treating clinical brain tumor patients by NCT and only two U.S. facilities, Massachusetts Institute of Technology (MIT) and Brookhaven National Laboratory (BNL). In addition to compound development, the UC Davis NCT program is preparing the UC Davis McClellan Nuclear Radiation Center's (MNRC) 2 megawatt TRIGA reactor for NCT clinical trials which would make it the only such facility on the West Coast.