Optical imaging device of retinal function

摘要

An optical imaging device of retina function (OID-RF) has been constructed to record changes in reflected 700nm light from the fundus caused by retinal activation in response to a visual 535nm stimulus. The resulting images reveal areas of the retina "activated" by visual stimulation. This device is a modified fundus camera designed to provide a patterned, moving visual stimulus over a 45 degree field of view to the subject in the green wavelength portion of the visual spectrum while simultaneously imaging the fundus in another, longer wavelength range. Data was collected from 3 normal subjects and recorded for 13 seconds at 4 Hz; 3 seconds were recorded during pre-stimulus baseline, 5 seconds during the stimulus, and 5 seconds post-stimulus. This procedure was repeated several times and, after image registration, the images were averaged to improve signal to noise. The change in reflected intensity from the retina due to the stimulus was then calculated by comparison to the pre-stimulus state. Reflected intensity from areas of stimulated retina began to increase steadily within 1 second after stimulus onset and decayed after stimulus offset. These results indicate that a functional optical signal can be recorded from the human eye.