Imaging Fluorescence Parameters by Bayesian Optical Diffusion Tomography

摘要

A Bayesian optimization scheme is presented for reconstructing fluorescent yield and lifetime, the absorption coefficient, and the scattering coefficient in turbid media, such as biological tissue. The method utilizes measurements at both the excitation and emission wavelengths for reconstructing all unknown parameters. The effectiveness of the reconstruction algorithm is demonstrated by simulation and by application to experimental data from a tissue phantom containing a fluorescent agent.