The development of bioresorbable Fe-Mn alloys for orthopedic implantation

摘要

Bioresorbable metals have immense potential to be used in the clinical treatment of a variety of soft and hard tissue injuries and disease. For many applications, the presence of a permanent device may cause severe negative effects and require re-intervention in the long-term. A transient support for a healing tissue is an attractive solution for orthopaedic and vascular interventions alike. For applications in bone fracture in particular, the human body requires fixation devices to support bone regrowth in the proper alignment, but only for a short period of time (typically 6-12 months). We aim to design bioresorbable materials to fill this gap in the current offerings of implants. One such material system with promising results is iron-manganese (Fe-Mn) alloys. Our goal is to tailor the material's corrosion rate, mechanical properties, and cellular interactions to support tissue healing and remodeling.