Improvement of Biocompatibility and Osteointegration of Zirconia Implants by Means of Bioactive Glass Coating: an Experimental Study in Animal

摘要

The present work aimed to evaluate the biological properties between the bioglass coated and uncoated zirconia implants. A total of 24 implants were retrieved. Bioglass coated and uncoated porous implants were implanted in the mandible of 4 dogs. At the experimental times of 4 and 8 weeks after sacrifice, the histological sections specimens of the implants and surrounding tissues were processed to determine the osteointegration rate; The other corresponding implants were processed for SEM microanalysis. A significantly higher affinity index was demonstrated in vivo by histomorphometric evaluation in coated versus uncoated implants. The osteointegration rates varied between 21.5% and 47.7% (cancellous bone), and between 28.0% and 56.8% (cortical bone), (p < 0.05). SEM analysis demonstrated better bone adhesion to the material in coated implant at any weeks. Coated implants are highly biocompatible and osteoconductive.