Multiple reactions monitoring for determinating cocaine and ethylbenzoylecgonine to increase the signaloise ratio in mass spectrometry analysis

摘要

Drug abuse consists of the use by a subject without a medical recommendation, in quantities or with non-recommended methods. Substance abuse also refers to their use in order to increase intellectual or physical performance, against the rules established by society. Substance abuse involves the chronic use of non-medical chemicals for hedonistic or entheogenic purposes. Drugs such as alcohol, antidepressants, amphetamine, barbiturates, benzodiazepines, cannabinoids, glue, cocaine, hallucinogens, metacular, narcotics, opiates, sedatives, stimulants and some organic solvents can be named. Substance abuse can cause criminal or antisocial behavior, may generate long-term changes in personality . Cocaine has major toxic effects on the body. Treatment of cocaine poisoning is complex. The main sales are those that can lead to patient death. For the proper treatment of any inoculation, it is necessary to identify the xenobiotic that generated it. The presence of metabolites, in the case of cocaine - ethylbenzoylcogene (EBE), provides information on the time of administration of the xenobiotic. Gas chromatography or liquid chromatography coupled with mass spectrometry is an optoelectronic method that can identify the presence of cocaine and / or EBE from biological samples. In order to increase the sensitivity of the method, a special mass metrology technique - MS/MS can be used.