Insulin Sensitivity and Plasma Glucose Appearance Profile by Oral Minimal Model in Normotensive and Normoglycemic Humans

摘要

To evaluate the whole body insulin sensitivity, S_(IW), and the rate of appearance, R_a(t), of ingested glucose into plasma, the oral minimal model of glucose kinetics (OMM) was applied to insulinemia and glycemia data from six volunteer, normotensive and normoglycemic subjects, who underwent a 300 min oral glucose tolerance test (OGTT). Results from a full 22-sampling schedule (OGTT_(300/22)), were compared with two reduced schedules consisting of 12 samples (OGTT_(300/12)) and 11 samples (OGTT_(300/11)), respectively. The three protocols yielded virtually the same values of insulin sensitivity (denoted as S_(IW)~(22), S_(IW)~(12) and S_(IW)~(11), respectively) with intraclass correlation coefficients being not lower than 0.74. The R_a(t) profiles reproduced by the OMM after application to the OGTT_(300/22) and the OGTT_(300/12) data were practically indistinguishable, whereas the profile obtained from the OGTT_(300/11) was characterized by a 33% overshoot at the 30th minute, followed by a 22% undershoot at the 60th minute. Our results suggest that the reduced OGTT_(300/12) is suitable to facilitate the assessment of insulin sensitivity and plasma glucose appearance profile in pathophysiological studies by the OMM.