Low-frequency noise reduction with solid-state nanopores by preventing surface charge fluctuation

摘要

To realize DNA sequencing with solid-state nanopore, reduction of an ionic current noise is an importantissue. Especially, low-frequency noise causes a serious problem for reducing read accuracy of DNAsequencing. The low-frequency noise consists of binary current fluctuations, and the noise is similar to theblockade current. To maximize the signal-to-noise ratio in DNA translocation, any baseline currentfluctuations should be minimized. Ever since the discovery of the noise, its origins have been heavily debated,but it has not yet clarified.