PREPARATION AND CHARACTERIZATION OF FAST DISSOLVING ORAL LYOPHILIZED WAFER OF CINNARIZINE FOR MOTION SICKNESS.

摘要

The fast-dissolving film of cinnarizine containing 4% HPMC E5 as film former and 20% glycerol as a plasticizer obtained by the solvent casting method showed acceptable mechanical characteristics and satisfactory % drug release. Thus by optimizing the film formulation patient compliance and oral bioavaibility both achieved.