Micellar Nanomedicine for PI3K Inhibition in Breast Cancer

机译：胶束纳米药物在乳腺癌中抑制PI3K的作用

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The PI3K/Akt/mTOR pathway has been found to be aberrantly activated in breast cancer. LY294002 (LY) PEG-PCL polymer micelles were developed as a nanotherapeutic platform to target breast tumors through inhibition of PI3K. Resulting micelles (-35 nm in diameter) displayed favorable drug loading and superb cell killing potential in in vitro breast tumors.

机译：已经发现PI3K / Akt / mTOR途径在乳腺癌中被异常激活。 LY294002（LY）PEG-PCL聚合物胶束被开发为一种纳米治疗平台，可通过抑制PI3K靶向乳腺肿瘤。所得的胶束（直径为-35 nm）在体外乳腺肿瘤中显示出良好的载药量和极好的细胞杀伤能力。

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来源
《Annual meeting exposition of the Controlled Release Society》|2010年|p.1215-1216|共2页
会议地点 Portland OR(US)
作者
E. Blanco; T. Sangai; F. Meric-Bernstam; M. Ferrari;
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Univeristy of Texas Health Science Center at Houston Houston TX 77031 USA;

University of Texas MD Anderson Cancer Center Houston TX 77030 USA;

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1. Inhibition of BTF3 sensitizes luminal breast cancer cells to PI3Kα inhibition through the transcriptional regulation of ERα [J] . Jinlei Ding, Xiaonan Wang, Yuan Zhang, Cancer letters . 2019,第期

机译：BTF3抑制通过ERα的转录调节使腔乳腺癌细胞敏感到PI3Kα的抑制作用
2. Mass Spectrometry-Based Proteomics Reveals Potential Roles of NEK9 and MAP2K4 in Resistance to PI3K Inhibition in Triple-Negative Breast Cancers [J] . Mundt Filip, Rajput Sandeep, Li Shunqiang, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2018,第10期

机译：基于质谱的蛋白质组学揭示了NEK9和MAP2K4在三阴性乳腺癌中抗PI3K抑制的潜在作用
3. TGF-β inhibition combined with cytotoxic nanomedicine normalizes triple negative breast cancer microenvironment towards anti-tumor immunity [J] . Myrofora Panagi, Chrysovalantis Voutouri, Fotios Mpekris, Theranostics . 2020,第4期

机译：TGF-β抑制联合细胞毒性纳米胺，核对抗肿瘤免疫力标准化三重阴性乳腺癌微环境
4. Precise Phage-navigating Breast Cancer-targeted Paclitaxel-Micell Nanomedicines [C] . Valery A. Petrenko, Vladimir P. Torchilin Annual techconnect world innovation conference expo;Defense techconnect DTS conference;Annual nanotech conference expo;SBIR/STTR innovation conference . 2018

机译：精确的噬菌体靶向乳腺癌靶向紫杉醇-Micell纳米药物
5. Targeting the MEK5, MEK1/2, and/or Pi3k Pathways Reverses Epithelial to Mesenchymal Transition and Enhances Chemotherapeutic Sensitivity in Breast and Brain Cancers with a Mesenchymal Phenotype [D] . Bhatt, Akshita B. 2021

机译：靶向MEK5，MEK1 / 2和/或PI3K途径将上皮细胞转型的上皮性反转，并通过间充质表型提高乳腺癌和脑癌中的化疗敏感性
6. Inhibition of the PI3K/mTOR Pathway in Breast Cancer to Enhance Response to Immune Checkpoint Inhibitors in Breast Cancer [O] . Chi Yan, Jinming Yang, Nabil Saleh, 2021

机译：抑制乳腺癌PI3K / mTOR途径增强乳腺癌中免疫检查点抑制剂的反应
7. TGF-β inhibition combined with cytotoxic nanomedicine normalizes triple negative breast cancer microenvironment towards anti-tumor immunity [O] . Myrofora Panagi, Chrysovalantis Voutouri, Fotios Mpekris, 2020

机译：TGF-β抑制联合细胞毒性纳米胺，核对抗肿瘤免疫力标准化三重阴性乳腺癌微环境
8. Approaching Resistance to Targeted Inhibition of PI3K in Breast Cancer [R] . Ilic, N. 2011

机译：接近对乳腺癌中靶向抑制pI3K的抗性

Micellar Nanomedicine for PI3K Inhibition in Breast Cancer

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