NNET: linking small- and large-scale network models

摘要

To examine how mechanistic principles derived in small networks are manifest in larger networks, we developed a versatile neuronal network simulator, NNET, in portable C++ code. NNET allows easy, fast and accurate characterization of any neuronal population and coupling pattern of electrical and chemical synapses. Using NNET, we simulated 30-cell networks of interneurons coupled with both gap junctions and GABAergic synapses, based on a mechanism derived in two-cell networks.