Volume Fraction-Corrected Mitotic Index In Prostate Cancer

摘要

Mitosis counting remains one of the most valuable prognostic indicators in tumour pathology. The aim of this study was to assess the proliferative activity of primary prostate cancer and lymph node metastases using the volume fraction-corrected mitotic index (M/V_v). Mitotic figures were quantitated as number of mitotic figures/mm~2 of neoplastic epithelium in a series of 40 prostatic adenocarcinomas, and the results were related to histologic features as well as to prognosis. Gleason score and mitotic indices were not significantly interrelated. High-grade tumours showed higher mitosis counts than intermediate-grade tumours, and metastasis was related to mitotic indeces as well. The results show that mitotic indeces are useful prognostic parameters in prostatic adenocarcinoma.