Time-domain terahertz spectroscopy of artificial skin

摘要

Time-domain Terahertz (THz) spectroscopy and imaging is currently evaluated as a novel tool for medical imaging and diagnostics. The application of THz-pulse imaging of human skin tissues and related cancers has been demonstrated recently in-vitro and in-vivo. With this in mind, we present a time-domain THz-transmission study of artificial skin. The skin samples consist of a monolayer of porous matrix of fibers of cross-linked bovine tendon collagen and a glycosaminoglycan (chondroitin-6-sulfate) that is manufactured with a controlled porosity and defined degradation rate. Another set of samples consists of the collagen monolayer covered with a silicone layer. We have measured the THz-transmission and determined the index of refraction and absorption of our samples between 0.1 and 3 THz for various states of hydration in distilled water and saline solutions. The transmission of the THz-radiation through the artificial skin samples is modeled by electromagnetic wave theory. Moreover, the THz-optical properties of the artificial skin layers are compared to the THz-optical properties of freshly excised human skin samples. Based on this comparison the potential use of artificial skin samples as photo-medical phantoms for human skin is discussed.