Study of Novel Biofunctional Polymer Surfaces

摘要

A great deal of research effort has been devoted to the design and synthesis of truly biocompatible polymer materials during the last few decades. A type of material in which bioactive macromolecules are immobilized on to the surface of polymer substrates, may be the most promising one of possessing true blood and/or cell compatibility. One of the best ways to develop the bioactive polymer surfaces is a simple and effective solution technique which may be called "solution seeding". Polystyrene(PS) is chosen as model polymer substrate. Octadecylpoly(ethylene oxide) and its derivatives (SPEO-R) serve as the modifying polymers, whose structure are C_(17)H_(36)COO(CH_2CH_2O)_nR. where R is sulfonate group, heparin. RGD, or amino acids( Arg. Lys. Arp. Asn and Gly).