PREPARATION AND EVALUATION OF Sn-117m ANNEXIN FOR VULNERABLE PLAQUE

摘要

1. High purity Sn-117m with specific activities of 15,000 - 20,000 Ci/g were achievable 2. Chelation of Sn-117m with ABD was achievable in close to quantitative yields 3. Sn-117m-ABD was used to conjugate to annexin with yields of 30-60 % 4. Sn-117m-annexin retained its biological activity in a cell binding test 5. Sn-117m-annexin gave positive results in two different mice models 6. Early stage clinical trials show targeting of the conjugate in vulnerable plaque 7. Early toxicology data show low toxicity for Sn-117m-annexin at therapeutic doses.