CURRENT IS KING: THE DIRECT PRODUCTION OF ~(99M)TC VIA THE ~(100)MO(P,2N) CHANNEL ON SMALL MEDICAL CYCLOTRONS

摘要

Using TR19 (18 MeV on target, 250 uA) and GE PETtrace 880 machines (16.5 MeV on target, 130 uA), our team has established preliminary saturated yields as high as 3.4±0.4 GBq/μA. Optimization continues on the PETtrace systems with early results suggesting yields exceeding 1.8 GBq/ uA. Preliminary data suggests ~(99m)Tc radionuclidic and radiochemical purity in excess of 99% is possible with an appropriate balance of ~(100)Mo isotopic purity, energy and irradiation time. Beam current is the most effective metric for boosting production yields while maximizing radionuclidic purity within an established set of production metrics.