A Case Study: The Development of a Cancer Clinical Trial Database System Using caCORE SDK

摘要

There are huge amounts of biomedical data generated in each research lab in each cancer center. The data are stored in various formats and accessed through various interfaces. It is very hard to interchange and integrate the data among different cancer centers, even among different research labs in the same cancer center, in order to discover useful cancer biomedical knowledge to serve the cancer healthcare community. The cancer Biomedical Informatics Grid (caBIG), an information network developed by the National Cancer Institute Center for Bioinformatics (NCICB) [1], is the solution to the interoperability among heterogeneous data systems. NCICB also developed a set of open source software to support the development of applications for caBIG. The cancer Common Ontologic Representation Environment (caCORE) SDK is the core software of caBIG. The caCORE paradigm addresses both aspects of interoperability: the ability to access data (syntactic interoperability) and understand the data once retrieved (semantic interoperability) [2]. In this poster, we will demonstrate the design and implementation of a cancer clinical trial database system using caCORE SDK 4.0. This database system is an industry-standard,three-tier distributed architecture which is shown in Figure 1. It has two parts: Data Entry and Data Access. Data entry functionality has a Web-based interface, which is provided by the OnCore system. Data access functionality is generated automatically by caCORE SDK 4.0 and deployed on the caGrid as the Data Grid Service(http://sisyphus.emory.edu: 18080/wcil 116-05Login ID: test1234, Password: 12jiyihui). It has four interfaces: Web-based, Java API,XML utility and Web service.