New approaches for the local prevention and treatment of fragilized osseous sites using doped-calcium phosphate cements

摘要

Here we demonstrate the feasibility of such medical device based on doped-calcium phosphate cement incorporating inhibitors of bone resorption in order to stimulate bone ingrowth. One can of course imagine to incorporate both gallium and bisphosphonate in the same cement which nevertheless raises the question of whether we are still dealing with a medical device. We also believe that the replacement of the aqueous liquid phase by blood is a promising way due to the presence of many circulating cells promoting bone healing. Preliminary "in vivo" experiments supports this assertion.