Variation of biological functions of hepatocytes between biodegradable and nonbiodegradable devices

摘要

Artificial liver made by tissue engineering has been proposed as a new potential therapy for liver dysfunction and failure. We investigated that the supportive role of biodegradable collagen matrices in simultaneous autotransplantation of hepatocytes after major liver resection, dynamic angiogenesis in biodegradable devices (BDD) and nondegradable devices (NDD) transplanted into the renal subcapsule and subcutaneous tissue, and the circulation, microvascular integrity, and capacities of endothelial cells (adhesion, proliferation, and migration) after subcutaneous transplantation of both devices. We also found that hepatocyte bioengineering by the use of a polymer device provided sufficient volume,