Heparin Immobilization onto Plasma Modified Polyethylene Terephthalate to Improve Blood Compatibility

摘要

Polymeric materials have been attracted many R&D attentions to be used in biomedical applications such as blood-contacting devices. Attempts were made to evaluate the changes in heamocompatibility properties of poly ethylene terephthalate surface by grafting acrylic acid(AAc) and immobilizing heparin on PET surface through two step plasma treatments for the first time. PET surface was modified by using a new method namely "two-step plasma treatments" (TSPT). In the first step, the films were pre-treated with low temperature glow discharge oxygen plasma and immersed into the aqueous monomer solution of AAc. The second step was carried out by plasma polymerizing of pre-adsorbed reactive monomer on the surfaces of dried pre-treated films. Finally,