In Silico White Blood Cell: A Synthetic Model of Leukocyte Rolling, Activation, and Adhesion During Inflammation

摘要

We have constructed a synthetic in silico model for representing the dynamics of leukocyte rolling, activation, and adhesion on substrate-coated flow chambers. Software components were designed, instantiated, verified, plugged together, and then operated in ways that can map concretely to mechanisms believed responsible for leukocyte rolling, activation, and adhesion. Here, we show our model's ability to represent data from in vitro flow chamber studies of leukocyte rolling, activation, and adhesion on P-Selectin, ICAM-1 and CXCL1 substrate-coated surfaces.