Lymph compartment models and HIV intra patient infection dynamics

摘要

A compartment model is proposed to describe the HIV infection in humans. The compartments describe the blood, several lymph nodes and connecting lymph vessels. The dynamics in each compartment are described by a simplified HIV model considering the healthy and infected T-cells. A bifurcation analysis based on the variation of the proliferation rate is discussed and supported by simulations. Additional simulations illustrate the effect of a simple mutation model.