Modeling of mRNA Translation using Petri Nets

摘要

Gene expression is a very complex process duernto the fact that a wide range of factors couldrncontribute to the process of gene expression,rnmRNA transcription and mRNA translation.rnFactor that can lead to the process of genernexpression and protein production can range fromrnenzymes, to signaling network, and so on.rnTechnical advances have always played a key rolernin improving our ability to understand genernexpression that could lead to treatment ofrndiseases. Computer modeling of mRNArnTranslation can provide an unprecedentedrnopportunity to study the process of proteinrnproduction. Simulation and analysis of the modelrnwill provide us with understanding of therninteraction of factors that are contributing in thernprocess of mRNA translation. However thernexponential growth in the volume of experimentalrninformation available makes it difficult forrnresearchers to assemble the details. To overcomernthis problem we propose the use of mathematicalrnapplications and modeling tools to model,rnsimulate and analyze the process of mRNArntranslation. In this paper as an ongoing researchrntoward complete and detailed model of genernexpression and protein production process, wernpropose a Petri Net model of the factors in thernprocess of mRNA translation at sub-molecular,rnmolecular, cellular, organ, system and clinicalrnphenotypic levels.