GENERALIZING THE THEORY OF MICRODIALYSIS

摘要

The efficiency of sampling or delivering solutes (analytes) by in vivo microdialysis is influenced by the diffusive permeabilities of the probe and the tissue in which the probe is implanted. In tissue, processes removing the analyte from the extracellular space are as important as diffusion in determining permeability. In addition to diffusion, analyte permeation through these media may be augmented or diminished by bulk fluid movement (transmembrane and interstitial convection). Within the perfu0sate, the dominant process is axial convection. Both diffusive and convective determinants of probe efficiency may be influenced by probe geometry (Figure 1; longitudinal cross-sectional view). The main geometric parameters are the probe membrane length and radii, but inner Camilla geometry can also be an appreciable factor.