Bond Graph Modeling of Pharmacodynamic Effect of Group IA Anti-arrhythmia Drugs on Ventricular Purkinje Cell Membrane Ionic Channels

摘要

In this paper, an analysis of the effect of group IA anti arrhythmia drugs upon ventricular purkinje cell ionic channels is provided. The computer simulation using MATLAB is based on bond graph modeling of the pharmacodynamic system with the emphasis on cell membrane behavior. Modeling of the transport of non-ionic particles through the semi-permeable biological membrane encompasses sthe four major transport mechanisms, namely, simple diffusion, channel protein transport, facilitated diffusion and active transport. Furthermore, ionic concentration gradient on both sides of the membrane leads to electrical potential gradient. This in turn affects the transport of ions. By catering for these interactions, the model is thus capable of showing the mutual effect of ionic concentration and ionic transport. The proposed model is then utilized to simulate the altering effect of an antiarrhythmia drug group upon ventricular Purkinje cell behavior. It is thus shown tat the causal description of physiological systems provided by bond graph modeling technique, could be a critical tool towards a better understanding of the interactions amongst subsystems, thereby gaining a more detailed description of the pathological states and the corresponding pharmacodynamic responses.