Evidence-Based Decision Support For The Biopharmaceutical Industry

摘要

We introduce and describe an evidential-based approach to drug development decision making. The approach treats decision-related data as evidence for or against pursuing competing development alternatives. A benefit of the proposed evidential approach is that decision makers are not forced to provide data, as in traditional decision analytic approaches, that are not available or cannot be obtained from reliable sources. As a consequence, the described approach is able to give better insight into the impact of assumptions, approximations, and uncertainty on multi-million dollar decisions. A summary of results from using an evidential approach to help identify false positive and false negative results is presented.