Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

摘要

The occurrence of concentrated pneumonia cases in Wuhancity, Hubei province of China was first reported on December 30, 2019 by the Wuhan Municipal Health Commission (WHO, 2020). The pneumonia cases were found to belinked to a large seafood and animal market in Wuhan, andmeasures for sanitation and disinfection were taken swiftlyby the local government agency. The Centers for DiseaseControl and Prevention (CDC) and Chinese health authorities later determined and announced that a novel coronavirus (CoV), denoted as Wuhan CoV, had caused thepneumonia outbreak in Wuhan city (CDC, 2020). Scientistsfrom multiple groups had obtained the virus samples fromhospitalized patients (Normile, 2020). The isolated viruseswere morphologically identical when observed underelectron microscopy.