Acute and Subacute Oral Toxicity of Periodate in Rats.

摘要

Subacute administration of sodium periodate via oral gavage resulted in a cascade of effects that were secondary to kidney toxicity. Decreased mass of ovaries and epididymides and testicular degeneration were observed in sodium periodate groups with signs of kidney toxicity. These groups also exhibited decreased T3 and T4 in the presence of decreased TSH, a pattern associated with uremia. Sodium periodate exposed rats exhibited both activation of the innate immune system and lymphocyte depletion; however, the pattern of effects was more indicative of a stress leukogram. Effects on the thymus and spleen in the absence of adrenal hyperplasia suggest more direct effects on the immune system. Decreased body mass observed in high dose groups was associated with gross and histopathologic findings in the gastrointestinal tract and may be related to effects on absorption. Increased cholesterol was identified as the critical endpoint and was used to derive the BMDL10s of 17.2 and 33.7 mg/kg-day for females and males, respectively.