METHOD FOR SIMULATION OF SUBACUTE LIVER EXPOSURE TO TOXIC FORMALIN

摘要

FIELD: medicine.;SUBSTANCE: formalin (CH₂O) is used, which is injected orally to male rats every day, at the rate of 0.1 ml per 100 g of animal weight, for 14 days. On day 14, animals are decapitate with subsequent laboratory tests and liver study. The model of subacute lesions caused by the oral introduction of formalin (CH₂O) is obtained, represented by increased degenerative processes in the liver, evolving creatininemia, increased transaminase level, development of cholestasis, and histologically proven by expressed degenerative damages of almost all sites of the liver.;EFFECT: method allows to obtain a model of subacute liver damage to be used in an experiment.;2 tbl