METHOD FOR PREDICTION OF SUBACUTE ANTHRACYCLINE-MEDIATED CARDIOTOXICITY DEVELOPMENT IN ONCOLOGICAL PATIENTS

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, particularly to cardio-oncology and medical genetics, and aims at predicting subacute anthracycline-mediated cardiotoxicity in oncological patients. Method includes genotyping polymorphism rs28714259 on a DNA matrix extracted from blood or buccal epithelium. If genotypes G / A or A / A are present, a high risk of subacute anthracycline-mediated cardiotoxicity is predicted.;EFFECT: invention provides a cheap, easy-to-implement high-information method for predicting the risk of anthracycline-mediated cardiotoxicity in oncological patients before using anthracycline antibiotics.;1 cl, 4 tbl, 3 ex