Chemoenzymatic Synthesis of Sialyl Lewis~x Glycopeptides

摘要

Invasive leukocytes play a decisive role in acute and chronic inflammation. They reach the site of inflammation through a multistep process initiated by "leukocyte rolling". This "rolling" is caused by the interaction of carbohydrate ligands on the surface of leukocytes and receptors, the E- and P-selectins. which are found on the surface of activated endothelial cells. A disruption of this early interaction is considered to be a promising therapeutic approach. The tetrasaccharide sialyl Lewis~x (SLe~x) and various derivatives have been identified as liaands for selectins.