Nickel-Catalyzed Formation of a Carbon-Nitrogen Bond at the β Position of Saturated Ketones

摘要

Ketone carbonyl groups can undergo a range of reactions at different sites. The positive carbonyl carbon center functions as an electrophile,' whereas the a position undergoes deprotonation in the presence of a base to act as a nucleophile. However, bond formation on the β-carbon atom of saturated ketones still remains unexplored. Herein, we describe a new catalytic formation of a carbon-nitrogen bond at the p position of alkyl ketones in the presence of a nickel complex.