天然植物抗假丝酵母菌活性成分的研究

摘要

The incidence of clinical fungal infections has increased dramatically,causing high morbidity and mortality.Currently,with extensive application of broad-spectrum antifungal agents,there has been a notable increase in drug resistance.In addition,lots of antifungal agents used have different degrees of side effects.Therefore,the development of new and effective antifungal agents is of paramount importance.Recently,studies on active constituents from natural plants have received more and more attention,due to its properties of abundance,low toxicity,broad spectrum and diverse ways of action.In this study,the study on screening active constituents from natural plants in recent years is reviewed.%临床真菌感染的发病率和死亡率逐年上升,其中以假丝酵母菌为代表的侵袭性真菌感染尤为严重,目前主要抗真菌药物的耐药性日趋严重,且多数具有毒副作用,寻找安全有效的新型抗真菌药物迫在眉睫.天然植物中抗真菌活性成分来源广泛,具有低毒、广谱、作用途径多样化等优点,成为新型抗真菌药物的一个重要研究方向.本文主要综述了近年来从天然植物中筛选抗假丝酵母菌活性成分的研究.