乳腺癌中雄激素受体的表达及其临床意义

摘要

Objective:To study the expression of androgen receptor(AR) in breast carcinoma and the relationship between clinicopahtological parameters.Methods:The expression of AR in 95 cases of breast carcinoma was evaluated using immunohistochemistry and analyzed the relationship between AR and clinicopahtological parameters.Results:The expression of AR in breast carcinoma was concerned with the diameter of tumour,there were high positive proportation of AR in the tumour less than 2cm in diameter(90％).It showed significant difference to the tumor more than 5cm(P =0.006) in diameter and showed no difference to the tumour 2-5cm in diameter(P =0.170).There was high positive proportation of AR in the grade one carcinoma(91.3％),and showed significant difference to the tumors with histological grade two and three(P =0.00275,P =0.0104).There were no difference in the tumor with different status of lymphnode metastatis.The expression of AR showed significant difference between clinical TNM stages Ⅰ,Ⅱ and stages Ⅲ,Ⅳ(P =0.034).Conclusion:The subtype of breast carcinoma with high proportation of AR expression may have low invasiveness and better prognosis.%目的:探讨女性乳腺癌组织中雄激素受体(AR)的表达状态与乳腺癌临床病理预后指标的关系.方法:应用免疫组织化学染色方法检测95例乳腺癌中AR的表达情况,并结合相关临床病理指标进行比较分析.结果:乳腺癌组织中AR的表达与肿瘤直径有关,肿瘤＜2cm者AR阳性率较高(90％),与肿瘤＞5cm者比较差异有统计学意义(P =0.006),但与2-5cm肿瘤比较差异无统计学意义(P =0.170).组织学分级1级者阳性表达率高(91.3％),与组织学分级2级及3级者比较差异有统计学差异(P=0.0275,P=0.0104),与淋巴转移无统计学差异.临床TNM分期Ⅰ、Ⅱ期病例与临床Ⅲ、Ⅳ期病例AR表达差异有统计学意义(P=0.034).结论:AR受体高表达类型的乳腺癌可能有较低的侵袭性及较好的预后.