Growth Inhibition of Shenfoweikang Herbs on Gastric Carcinoma Via Signal Transduction Pathways

摘要

To verify the anti-tumor effect of the Shenfoweikang on gastric cancer, BALB/C mice grafted with a mouse gastric adenocarcinoma cell line MFC was used as the experimental model. The mice received Shenfoweikang herbs over a 60-day period starting at the first day. The tumor size was periodically measured. Apoptotic indices (AI) were examined by the TUNEL method and flow cytometric analysis. The expression of VEGF, STAT3 and DEC1 in tumor tissues was examined by immunostaining. Compared with the control group, tumor growth in the mice treated with Shenfoweikang decoction were significantly inhibited (P<0.05). AI in the mice was significantly increased after the Shenfoweikang decoction treatment. The expressions of VEGF, STAT3 and DEC1 in tumor tissues were down-regulated after treated with Shenfoweikang decoction. The anti-tumor effect of Shenfoweikang herbs is related with the induction of the cell apoptosis and down-regulation of VEGF, STAT3 and DEC1 signal transduction system.