Adropin - A Novel Secreted Factor Linking Diet with Energy Homeostasis

摘要

Organisms must adapt substrate preference and energy expenditure to daily changes in dietary macronutrient intake and energy status. An impaired capacity for metabolic adaptation may increase risk for weight gain and insulin resistance [1,2]. The adaptive response involves an integrated response involving the central nervous system and several peripheral organ systems, with the liver having a central role in coordinating processing and distribution of metabolites [3]. Endocrine signals play a role in this process. Classical examples include insulin, glucagon, leptin, and adiponectin. We recently identified a novel liver secreted factor named adropin which is encoded by the Energy Homeostasis Associated transcript (Enho). Enho expression is altered by macronutrient content of the diet and fasting, and is proposed to have important role in maintaining energy homeostasis by regulating lipid and glucose metabolism [4]. Here we briefly summarize the identification of the Enho transcript and adropin, and present some of unpublished data from the analysis of FVB/NJ mice over expressing adropin.