Extraction of tissue optical parameters from diffuse reflectance measurements with a new able to count derivatives inverse Monte Carlo method

摘要

A new method for non-invasive determination of optical parameters (absorption and reduced scattering coefficients) ofbiological tissues from diffuse reflectance measurements with a multifiber probe is presented. For extraction of theparameters, we use a priori estimations not only of signals of detectors, but also their parameter derivatives that increasesaccuracy of the extraction. This estimation is performed using a new non-analog Monte Carlo algorithm which allows usto calculate the signals and derivatives simultaneously for a given large set of optical parameters. Experimental testinghas shown the measured coefficients provide a good prediction of both light reflection and penetration. Application ofthe method to some biological tissues are presented.