Preliminary Monte Carlo based Inverse Model to Extract Optical Tissue Properties from Experimental Diffuse Reflectance Measurements Coefficients Extraction for Gastrointestinal Dysplasia Detection

摘要

The ability to detect cancer at its earliest stages, called “dysplasia”, is the key of its successful treatment. Optical techniques, such as diffuse reflectance and intrinsic fluorescence, may improve the ability to detect gastrointestinal (GI) dysplasia since they have the potential to provide morphological and biochemical information of normal and malignant tissues. However, those optical tissue properties can only be provided if it is possible to extract information from the measured diffuse reflectance and intrinsic fluorescence signals. This paper presents the implementation and the validation of a preliminary Monte Carlo based inverse model to extract optical tissue properties, such as the absorption and the scattering coefficients, from diffuse reflectance experimental measurements in phantoms.